Abstract Title:

Resveratrol inhibits isoprostane production in young and aged rat brain.

Abstract Source:

Mol Cells. 2008 Nov 30;26(5):486-9. PMID: 21122283

Abstract Author(s):

A Chiavaroli, L Brunetti, G Orlando, L Recinella, C Ferrante, S Leone, P Di Michele, C Di Nisio, M Vacca

Article Affiliation:

Department of Drug Sciences, G. d'Annunzio University, Chieti, Italy.


Resveratrol (3,5,4-trihydroxystilbene), a viniferin polyphenolic compound, has been shown to have neuroprotective effects and we tested its possible antioxidant activity in young and aged rat brain, evaluating, in vitro, synaptosomal 8-iso-prostaglandin F2alpha (8-iso-PGF2alpha) production as a marker of oxidative stress. We found that in young rat brain synaptosomes resveratrol perfusion had no effect on basal 8-iso-PGF2alpha production, but quenched to basal levels the increased 8-iso-PGF2alpha production induced by hydrogen peroxide. On the other hand, in aged rats, resveratrol was able to decrease 8-iso-PGF2alpha production both basally and after hydrogen peroxide-induced oxidative stimulus. In conclusion, our findings show that the antioxidant effects of resveratrol in rat brain could play a neuroprotective role in aging, when the increased burden of oxidative stress is faced by defective antioxidant mechanisms.

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