Abstract Title:

Resveratrol, a remarkable inhibitor of ribonucleotide reductase.

Abstract Source:

FEBS Lett. 1998 Jan 16;421(3):277-9. PMID: 9468322

Abstract Author(s):

M Fontecave, M Lepoivre, E Elleingand, C Gerez, O Guittet

Article Affiliation:

Laboratoire de Chimie et Biochimie des Centres Redox Biologiques, DBMS-CEA/CNRS/Universit√© Joseph Fourier, Grenoble, France. [email protected]


Resveratrol, a natural phytoalexin found in grapes, is well known for its presumed role in the prevention of heart disease, associated with red wine consumption. We show here that it is a remarkable inhibitor of ribonucleotide reductase and DNA synthesis in mammalian cells, which might have further applications as an antiproliferative or a cancer chemopreventive agent in humans.

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