Abstract Title:

[Research on resveratrol's effects on suppressing growth and inducing apoptosis of GBC cells].

Abstract Source:

Zhong Yao Cai. 2005 Jun;28(6):489-91. PMID: 16209266

Abstract Author(s):

Li Sheng, Lifeng An, Ye He, Guixiang Fan, Yukang Yuan

Article Affiliation:

Department of Immunology, Medical College, Xi'an Jiaotong University, Xi'an.


OBJECTIVE: To explore the contribution of resveratrol (Res) to the proliferation and apoptosis of gallbladder carcinoma (GBC) cell line as well as fibroblast 3T3 cell line in vitro. METHODS: The tumor cell growth repressing rate was measured by the MTT method,and flow cytometry was used to analyse cell cycle. The gene expression of bcl-2 c-myc p53 were examined by SABC. RESULTS: Res obviously suppressed the proliferation (P<0. 01) in concentration and time dependent manner, it's tiptop was 54%. Res could induce apoptosis of tumor cells. The maximum apoptosis rate of tumor was 30. 52%, experiment group compared with comparison group Gl's cells rised from 34. 88% to 55.47 +/- 3. 95%, S's cells reduced 8.41 - 17.54%, which showed obvious phenomenon of G0/G1 blocking. The GBC cell's bcl-2, c-myc gene reduced expression,while p53 gene increased expression. CONCLUSION: The results of this study confirm the ability of Res to suppress the proliferation of gallbladder carcinoma (GBC) cell with a typical apoptotic feature in vitro. Therefore, Res may be considered as a possible treatment strategy for gallbladder carcinoma.

Study Type : In Vitro Study

Print Options

Key Research Topics

Sayer Ji
Founder of GreenMedInfo.com

Subscribe to our informative Newsletter & get Nature's Evidence-Based Pharmacy

Our newsletter serves 500,000 with essential news, research & healthy tips, daily.

Download Now

500+ pages of Natural Medicine Alternatives and Information.

This website is for information purposes only. By providing the information contained herein we are not diagnosing, treating, curing, mitigating, or preventing any type of disease or medical condition. Before beginning any type of natural, integrative or conventional treatment regimen, it is advisable to seek the advice of a licensed healthcare professional.

© Copyright 2008-2022 GreenMedInfo.com, Journal Articles copyright of original owners, MeSH copyright NLM.