Article Publish Status: FREE
Abstract Title:

Reversing chemoresistance of malignant glioma stem cells using gold nanoparticles.

Abstract Source:

Int J Nanomedicine. 2013 ;8:689-702. Epub 2013 Mar 1. PMID: 23467447

Abstract Author(s):

Anamaria Orza, Olga Soriţău, Ciprian Tomuleasa, Liliana Olenic, Adrian Florea, Ovidiu Pana, Ioan Bratu, Emoke Pall, Stefan Florian, Dan Casciano, Alexandru S Biris

Article Affiliation:

Anamaria Orza


The low rate of survival for patients diagnosed with glioblastoma may be attributed to the existence of a subpopulation of cancer stem cells. These stem cells have certain properties that enable them to resist chemotherapeutic agents and ionizing radiation. Herein, we show that temozolomide-loaded gold nanostructures are efficient in reducing chemoresistance and destroy 82.7% of cancer stem cells compared with a 42% destruction rate using temozolomide alone. Measurements of in vitro cytotoxicity and apoptosis indicate that combination with gold facilitated the ability of temozolomide, an alkylating drug, to alter the resistance of these cancer stem cells, suggesting a new chemotherapy strategy for patients diagnosed with inoperable recurrent malignant glioma.

Study Type : In Vitro Study

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