n/a
Abstract Title:

Reversing resistance of multidrug-resistant hepatic carcinoma cells with parthenolide.

Abstract Source:

Future Oncol. 2013 Apr ;9(4):595-604. PMID: 23560381

Abstract Author(s):

Dajun Liu, Ying Liu, Minghua Liu, Limei Ran, Yan Li

Article Affiliation:

Dajun Liu

Abstract:

AIM: To investigate the mechanism of reversing resistance of a hepatic carcinoma multidrug-resistant cell BEL-7402/5-FU with parthenolide (PTL).

MATERIALS & METHODS: BEL-7402/5-FU cells were treated with different concentrations of PTL and/or 5-fluorouracil. The proliferation inhibition rates, NF-κB, P-glycoprotein, MRP, Bcl-2, WNT1 and p53 levels were determined.

RESULTS: The results showed that PTL did not only have proliferation inhibition influence on BEL-7402/5-FU in a concentration-dependent manner, but also significantly increased the proliferation inhibition role of 5-fluorouracil on BEL-7402/5-FU, to reverse the resistance of hepatic carcinoma-resistant cells. PTL could also inhibit the NF-κB activity and the expression of P-glycoprotein, MRP, Bcl-2 and WNT1, and increase the expression of p53.

CONCLUSION: Our research suggests that clinical administration of PTL may be useful for hepatic carcinoma patients.

Print Options


This website is for information purposes only. By providing the information contained herein we are not diagnosing, treating, curing, mitigating, or preventing any type of disease or medical condition. Before beginning any type of natural, integrative or conventional treatment regimen, it is advisable to seek the advice of a licensed healthcare professional.

© Copyright 2008-2024 GreenMedInfo.com, Journal Articles copyright of original owners, MeSH copyright NLM.