Abstract Title:

Antineoplaston treatment for advanced hepatocellular carcinoma.

Abstract Source:

Oncol Rep. 1998 Nov-Dec;5(6):1363-7. PMID: 9769368

Abstract Author(s):

T Kumabe, H Tsuda, M Uchida, Y Ogoh, N Hayabuchi, M Sata, O Nakashima, H Hara

Article Affiliation:

Department of Radiology, Kumabe Hospital, Kurume University School of Medicine, Kurumeshi, Fukuokaken 830-0011, Japan.


Antineoplaston A10 injection (antineoplaston A10 I) exhibited cystostatic growth inhibition of human hepatocellular carcinoma (HCC) cells in vitro and showed minimum adverse effects in a phase I clinical trial. Advanced HCC is hard to control because the potent anticancer drugs or embolizations easily induce hepatic failure. We review herein 2 cases of advanced HCC treated with antineoplaston A10 I. Both cases showed interesting responses to antineoplaston A10 I. One showed massive coagulation necrosis of tumors after intra-arterial infusion of antineoplaston A10 I and the other showed resolution of portal vein tumor thrombosis with systemic infusion of antineoplaston A10 I. The usefulness of anti-neoplaston A10 I in terminal staged HCC is discussed.

Study Type : Human: Case Report, Review

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