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Abstract Title:

From Kratom to mitragynine and its derivatives: physiological and behavioural effects related to use, abuse, and addiction.

Abstract Source:

Neurosci Biobehav Rev. 2013 Feb ;37(2):138-51. Epub 2012 Dec 1. PMID: 23206666

Abstract Author(s):

Zurina Hassan, Mustapha Muzaimi, Visweswaran Navaratnam, Nurul H M Yusoff, Farah W Suhaimi, Rajakumar Vadivelu, Balasingam K Vicknasingam, Davide Amato, Stephan von Hörsten, Nurul I W Ismail, Nanthini Jayabalan, Ammar I Hazim, Sharif M Mansor, Christian P Müller

Article Affiliation:

Zurina Hassan

Abstract:

Kratom (or Ketum) is a psychoactive plant preparation used in Southeast Asia. It is derived from the plant Mitragyna speciosa Korth. Kratom as well as its main alkaloid, mitragynine, currently spreads around the world. Thus, addiction potential and adverse health consequences are becoming an important issue for health authorities. Here we reviewed the available evidence and identified future research needs. It was found that mitragynine and M. speciosa preparations are systematically consumed with rather well defined instrumentalization goals, e.g. to enhance tolerance for hard work or as a substitute in the self-treatment of opiate addiction. There is also evidence from experimental animal models supporting analgesic, muscle relaxant, anti-inflammatory as well as strong anorectic effects. In humans, regular consumption may escalate, lead to tolerance and may yield aversive withdrawal effects. Mitragynine and its derivatives actions in the central nervous system involveμ-opioid receptors, neuronal Ca²⁺ channels and descending monoaminergic projections. Altogether, available data currently suggest both, a therapeutic as well as an abuse potential.

Study Type : Review
Additional Links
Pharmacological Actions : Analgesics : CK(3498) : AC(646)

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