Abstract Title:

Non-enzymatic cyclic oxygenated metabolites of omega-3 polyunsaturated fatty acid: Bioactive drugs?

Abstract Source:

Biochimie. 2016 Jan ;120:56-61. Epub 2015 Jun 23. PMID: 26112019

Abstract Author(s):

Jérôme Roy, Jean-Yves Le Guennec, Jean-Marie Galano, Jérôme Thireau, Valérie Bultel-Poncé, Marie Demion, Camille Oger, Jetty Chung-Yung Lee, Thierry Durand

Article Affiliation:

Jérôme Roy


Non-enzymatic oxygenated metabolites derived from polyunsaturated fatty acids (PUFA) are formed in vivo through free radical reaction under oxidative stress conditions. It has been over twenty-five years since the discovery of cyclic oxygenated metabolites derived from arachidonic acid (20:4 n-6), the isoprostanes, and since then they have become biomarkers of choice for assessing in vivo OS in humans and animals. Chemical synthesis of n-3 PUFA isoprostanoids such as F3-Isoprostanes from eicosapentaenoic acid (20:5 n-3), and F4-Neuroprostanes from docosahexaenoic acid (22:6 n-6) unravelled novel and unexpected biological properties of such omega-3 non-enzymatic cyclic metabolites as highlighted in this review.

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