A review of e-cigarettes and cancer risk. - GreenMedInfo Summary
E-cigarettes and Cancer Risk.
Cancer Prev Res (Phila). 2019 Oct 16. Epub 2019 Oct 16. PMID: 31619443
From the time of their introduction, the popularity of e-cigarettes (electronic nicotine delivery systems) has been rising. This trend may reflect the general belief that e-cigarettes are a less hazardous alternative to combustible cigarettes. However, the potential cancer-related effects of increased activation of the sympathoadrenal system induced by the inhalation of nicotine, the primary component of the e-cigarettes, is completely overlooked. Therefore, the aim of this review is to describe mechanisms that may connect the use of e-cigarettes and an increased risk for cancer development, as well as their stimulatory effect on cancer progression. Available pre-clinical data indicate that activation of the sympathetic nervous system by nicotine inhaled from e-cigarettes may simulate cancer development and growth by several mechanisms. This issue might be especially important for oncological patients as they may have the misconception that compared to combustible cigarettes, e-cigarettes represent a risk-free alternative.