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Article Publish Status: FREE
Abstract Title:

Hesperidin: A Therapeutic Agent For Obesity.

Abstract Source:

Drug Des Devel Ther. 2019 ;13:3855-3866. Epub 2019 Nov 12. PMID: 32009777

Abstract Author(s):

Haijun Xiong, Jin Wang, Qian Ran, Guanhua Lou, Chengyi Peng, Qingxia Gan, Ju Hu, Jilin Sun, Renchuan Yao, Qinwan Huang

Article Affiliation:

Haijun Xiong

Abstract:

Obesity is a chronic metabolic disease caused by multiple factors and is considered to be a risk factor for type 2 diabetes, cardiovascular disease, hypertension, stroke and various cancers. Hesperidin, a flavanone glycoside, is a natural phenolic compound with a wide range of biological effects. Mounting evidence has demonstrated that hesperidin possesses inhibitory effect against obesity diseases. Our review discusses mechanisms of hesperidin in the treatment of obesity. Hesperidin regulates lipid metabolism and glucose metabolism by mediating AMPK and PPAR signaling pathways, directly regulates antioxidant index and anti-apoptosis, and indirectly mediates NF-κB signaling pathway to regulate inflammation to play a role in the treatment of obesity. In addition, hesperidin-enriched dietary supplements can significantly improve symptoms such as postprandial hyperglycemia and hyperlipidemia. Further clinical trials are also required for confirming lipid-lowering efficacy of this natural flavonoid and evaluating its safety profile.

Study Type : Review

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Sayer Ji
Founder of GreenMedInfo.com

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