Abstract Title:

Immunomodulatory Role of Vitamin D: A Review.

Abstract Source:

Adv Exp Med Biol. 2018 Aug 26. Epub 2018 Aug 26. PMID: 30143987

Abstract Author(s):

Agnieszka Skrobot, Urszula Demkow, Małgorzata Wachowska

Article Affiliation:

Agnieszka Skrobot


Vitamin D is well known for its classical hormonal action related to the maintenance of mineral and skeletal homeostasis. However, the discovery that vitamin D receptor (VDR) is expressed in most non-skeletal tissues points to its broad role in the human organism. Current literature emphasizes a multidirectional role of vitamin D, with a special focus on its immunomodulatory properties. As VDR and the enzyme 1-α-hydroxylase are expressed in most immune cells, vitamin D modulates the phagocytic activity of macrophages and natural killer cells. In addition, it induces the microbicidal activity of phagocytes. In contrast, vitamin D suppresses differentiation and maturation of antigen-presenting dendritic cells and B lymphocytes, and it inhibits proliferation of Th1 and Th17 cells. In this review we aimed to describe the current scientific discoveries on the role of vitamin D as immunomodulator.

Study Type : Review

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Sayer Ji
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