A review study on the effect of Iranian herbal medicines againstreplication of herpes simplex virus.
Avicenna J Phytomed. 2016 Sep-Oct;6(5):506-515. PMID: 27761420
OBJECTIVE: There are a number of published data indicatinganti-HSV activity of some of Iranian herbal extracts with no systematic review to discuss these results. Therefore, this article was aimed to review and discuss the methods carried out and the phytochemistry and bioactivity of the extracts used and also conclusions provided in these publications.
MATERIALS AND METHODS: Published articles both in English (from Medline, Science Direct, EMBASE, Scopus, Pro Quest, Google scholar, Cochrane Library) and in Persian (from SID, Iran Medex and Magiran) databases, from 1966 to October 2014 were incorporated in this review. Thestudies that lacked CC, IC, were excluded.
RESULTS: Only 42 published reports were found to examine Iranian herbs against HSV replicationSeventeen out of 42 studies in which 23 kinds of medicinal plants were subjected to crude extraction were included. The review of data showed that some of the herbal extracts includingmethanolic extract,aqueous extract,L. hydroalcoholic extract andmethanolic extract with selective index (SI) of 234, 877,>778 and 250, respectively were highly effective against HSV
CONCLUSION: More comprehensive studies using more advanced methods are needed to be done to achieve promising anti-HSV agents from the bioactive compounds isolated from these herbs.