Article Publish Status: FREE
Abstract Title:

Rhubarb Anthraquinones Protect Rats against Mercuric Chloride (HgCl₂)-Induced Acute Renal Failure.

Abstract Source:

Molecules. 2016 ;21(3). Epub 2016 Mar 8. PMID: 27005597

Abstract Author(s):

Dan Gao, Ling-Na Zeng, Pin Zhang, Zhi-Jie Ma, Rui-Sheng Li, Yan-Ling Zhao, Ya-Ming Zhang, Yu-Min Guo, Ming Niu, Zhao-Fang Bai, Xiao-He Xiao, Wei-Wei Gao, Jia-Bo Wang

Article Affiliation:

Dan Gao


Mercury (Hg) causes severe nephrotoxicity in subjects with excess exposure. This work attempted to identify whether a natural medicine-rhubarb-has protective effects against mercuric chloride (HgCl₂)-induced acute renal failure (ARF), and which of its components contributed most to the treatment. Total rhubarb extract (TR) were separated to the total anthraquinones (TA), the total tannins (TT) and remaining component extract (RC). Each extract was orally pre-administered to rats for five successive days followed by HgCl₂ injection to induce kidney injury. Subsequently, renal histopathology and biochemical examinations were performed in vitro to evaluate the protective effects. Pharmacological studies showed that TR and TA, but not TT or RC manifested significant protection activityagainst HgCl₂-induced ARF. There were also significant declines of serum creatine, urea nitrogen values and increases of total protein albumin levels in TR and TA treated groups compared to HgCl₂ alone (p<0.05). At last, the major components in TA extract were further identified as anthraquinones by liquid chromatography coupled mass spectroscopy. This study thus provides observational evidences that rhubarb could ameliorate HgCl₂-induced ARF and its anthraquinones in particular are the effective components responsible for this activity in rhubarb extract.

Study Type : In Vitro Study

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