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Article Publish Status: FREE
Abstract Title:

Ameliorates High-Fat-Diet-Induced Obesity by Elevating Peripheral Thermogenic Signaling.

Abstract Source:

Molecules. 2022 Mar 2 ;27(5). Epub 2022 Mar 2. PMID: 35268752

Abstract Author(s):

Yuna Lee, Yeo-Jin Park, Bonggi Lee, Eunkuk Park, Hail Kim, Chun-Whan Choi, Min-Soo Kim

Article Affiliation:

Yuna Lee

Abstract:

has been consumed as a food and as a traditional medicine for treating autoimmune diseases and aging in diverse countries. A previous study showed that a mixture ofandprohibited adipocyte differentiation and lipid accumulation in preadipocytes and suppressed diet-induced obesity. Nevertheless, the mechanism ofto regulate energy homeostasis solely through thermogenic signaling remains unclear. Thus, we investigated its effects on energy homeostasis usingfed to C57BL/6 mice with a 45% high-fat diet. Chronic consumption ofdecreased the body weight of obese mice with increasing food intakes and improved metabolic-syndrome-related phenotypes. Therefore, we further tested its thermogenic effects. Cold chamber experiments and qPCR studies indicated thatelevated thermogenic signaling pathways, demonstrated by increased body temperature and uncoupling protein 1 (UCP1) signaling in the white and brown adipose tissues. Afzelin is one major known compound derived from. Hence, the isolated compound afzelin was treated with preadipocytes and brown adipocytes for cell viability and luciferase assay, respectively, to further examine its thermogenic effect. The studies showed that the response of afzelin was responsible for cell viability and the increased UCP1. In conclusion, our data indicated thatelevated peripheral thermogenic signaling through increased UCP1 via afzelin activation and ameliorated diet-induced obesity.

Study Type : Animal Study

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