Abstract Title:

Highly purified vitamin B2 presents a promising therapeutic strategy for sepsis and septic shock.

Abstract Source:

Infect Immun. 2004 Mar;72(3):1820-3. PMID: 14977995

Abstract Author(s):

Toshio Toyosawa, Mamoru Suzuki, Kohtarou Kodama, Seiichi Araki

Article Affiliation:

Tsukuba Research Laboratories, Eisai Co., Ltd., Tsukuba, Ibaraki 300-2635, Japan.


Highly purified vitamin B2 (riboflavin 5'-sodium phosphate; purity>97%) treatment by intravenous infusion at doses above those used clinically to treat vitamin B2 deficiency showed therapeutic effects in mice not only in cases of endotoxin- and exotoxin-induced shock but also in cases of gram-negative and gram-positive bacterial infection even after the toxemia had already begun.

Study Type : Animal Study

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