Abstract Title:

Suppressive effects of coffee on the SOS responses induced by UV and chemical mutagens.

Abstract Source:

Mutat Res. 1986 Oct ;175(2):47-50. PMID: 3093858

Abstract Author(s):

H Obana, S Nakamura, R Tanaka


SOS-inducing activity of UV or chemical mutagens (AF-2, 4NQO and MNNG) was strongly suppressed by instant coffee in Salmonella typhimurium TA1535/pSK1002. As decaffeinated instant coffee showed a similarly strong suppressive effect, it would seem that caffeine, a known inhibitor of SOS responses, is not responsible for the effect observed. The suppression was also shown by freshly brewed coffee extracts. However, the suppression was absent in green coffee-bean extracts. These results suggest that coffee contains some substance(s) which, apart from caffeine, suppresses SOS-inducing activity of UV or chemical mutagens and that the suppressive substance(s) are produced by roasting coffee beans.

Study Type : Review

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