Abstract Title:

The Role of Polyphenol (Flavonoids) Compounds in the Treatment of Cancer Cells.

Abstract Source:

Nutr Cancer. 2019 Jul 9:1-12. Epub 2019 Jul 9. PMID: 31287738

Abstract Author(s):

Abu Hazafa, Khalil-Ur- Rehman, Nazish Jahan, Zara Jabeen

Article Affiliation:

Abu Hazafa


Cancer remains a second leading cause of deaths and major public health problem. It occurs due to extensive DNA damage caused by ultraviolet radiations, ionizing radiations, environmental agents, therapeutic agents, etc. Among all cancers, the most frequently diagnosed cancers are lung (12.7%), breast (10.9%), colorectal (9.7%), and gastric cancer (7.81%). Natural compounds are most favorable against cancer on the count of their anti-cancerous ability, easy to avail and efficient. Among natural compounds, polyphenols (flavonoids, catechin, hesperetin, flavones, quercetin, phenolic acids, ellagic acid, lignans, stilbenes, etc.) represent a large and diverse group used in the prevention and treatment of cancer. Natural flavonoids are derived from different plant sources and from various medicinal plants including,,,, etc. Natural flavonoids possess antioxidant, anti-inflammation, as well as anti-cancerous activities through multiple pathways, they induce apoptosis in breast, colorectal, and prostate cancers, lower the nucleoside diphosphate kinase-B activity in lung, bladder and colon cancers, inhibit cell-proliferation and cell cycle arrest by suppressing the NF-kB pathway in various cancers, etc. The current review summarized the anticancer activities of natural polyphenols and their mechanisms of action. Abbreviations Akt pathway A Serine/Threonine-Protein Kinase pathway COX-2 Cyclooxygenase-2 HaCaT Cultured Human Keratinocyte HDAC Histone Deacetylase MAPK pathway Mitogen-Activated Protein Kinases pathway (Oestrogen Receptor); NF-kBkappa-light-chain-enhancer of activated B cell PARP Poly ADP Ribose Polymerase ROS Reactive oxygen Speciese STAT-1 Signal Transducer and Activator of Transcription 1.

Print Options

Sayer Ji
Founder of GreenMedInfo.com

Subscribe to our informative Newsletter & receive The Dark Side of Wheat Ebook

Our newsletter serves 500,000 with essential news, research & healthy tips, daily.

Download Now

The Dark Side of Wheat

This website is for information purposes only. By providing the information contained herein we are not diagnosing, treating, curing, mitigating, or preventing any type of disease or medical condition. Before beginning any type of natural, integrative or conventional treatment regimen, it is advisable to seek the advice of a licensed healthcare professional.

© Copyright 2008-2023 GreenMedInfo.com, Journal Articles copyright of original owners, MeSH copyright NLM.