Article Publish Status: FREE
Abstract Title:

The Role of Zinc and Zinc Homeostasis in Macrophage Function.

Abstract Source:

J Immunol Res. 2018 ;2018:6872621. Epub 2018 Dec 6. PMID: 30622979

Abstract Author(s):

Hong Gao, Wei Dai, Lu Zhao, Junxia Min, Fudi Wang

Article Affiliation:

Hong Gao


Zinc has long been recognized as an essential trace element, playing roles in the growth and development of all living organisms. In recent decades, zinc homeostasis was also found to be important for the innate immune system, especially for maintaining the function of macrophages. It is now generally accepted that dysregulated zinc homeostasis in macrophages causes impaired phagocytosis and an abnormal inflammatory response. However, many questions remain with respect to the mechanisms that underlie these processes, particularly at the cellular and molecular levels. Here, we review our current understanding of the roles that zinc and zinc transporters play in regulating macrophage function.

Study Type : Review
Additional Links
Pharmacological Actions : Immunomodulatory : CK(5935) : AC(2191)

Print Options

Key Research Topics

This website is for information purposes only. By providing the information contained herein we are not diagnosing, treating, curing, mitigating, or preventing any type of disease or medical condition. Before beginning any type of natural, integrative or conventional treatment regimen, it is advisable to seek the advice of a licensed healthcare professional.

© Copyright 2008-2024 GreenMedInfo.com, Journal Articles copyright of original owners, MeSH copyright NLM.