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Article Publish Status: FREE
Abstract Title:

The Role of Zinc and Zinc Homeostasis in Macrophage Function.

Abstract Source:

J Immunol Res. 2018 ;2018:6872621. Epub 2018 Dec 6. PMID: 30622979

Abstract Author(s):

Hong Gao, Wei Dai, Lu Zhao, Junxia Min, Fudi Wang

Article Affiliation:

Hong Gao

Abstract:

Zinc has long been recognized as an essential trace element, playing roles in the growth and development of all living organisms. In recent decades, zinc homeostasis was also found to be important for the innate immune system, especially for maintaining the function of macrophages. It is now generally accepted that dysregulated zinc homeostasis in macrophages causes impaired phagocytosis and an abnormal inflammatory response. However, many questions remain with respect to the mechanisms that underlie these processes, particularly at the cellular and molecular levels. Here, we review our current understanding of the roles that zinc and zinc transporters play in regulating macrophage function.

Study Type : Review
Additional Links
Pharmacological Actions : Immunomodulatory : CK(5935) : AC(2191)

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