Article Publish Status: FREE
Abstract Title:

Rosmarinic Acid/ Blue Light Combination Treatment Inhibits Head and Neck Squamous Cell Carcinoma.

Abstract Source:

Anticancer Res. 2020 Feb ;40(2):751-758. PMID: 32014917

Abstract Author(s):

Christi N Waer, Preet Kaur, Zohra Tumur, Dee Dee Hui, Bonnie LE, Carlos Guerra, Bradley Henson, Dalia Seleem, Jill Lewis

Article Affiliation:

Christi N Waer


BACKGROUND/AIM: This study investigated a novel combined therapy of rosmarinic acid (RA)/blue light on head and neck squamous cell carcinoma (HNSCC) cell proliferation in vitro.

MATERIALS AND METHODS: HNSCC cells were exposed to BL (500 mW/cm) for 90 s, and incubated with 80μg/ml RA for 1 hour. Cell viability was determined after 24 h using WST-1 assay. Western blot was used to detect treatment-induced changes in epidermal growth factor receptor (EGFR) activation. Hydrogen peroxide (HO) and nitric oxide levels were quantified using CM-HDCFH-DA assays. Apoptosis was assessed using Annexin V/PI staining and flow cytometry.

RESULTS: RA/blue light treatment resulted in a significant reduction in cell viability, EGFR activation and HOlevels in all HNSCC cell lines. However, no significant changes in NO production or apoptosis induction were found.

CONCLUSION: RA/blue light effectively decreased HNSCC cell proliferation through reduction in EGFR activation and HOproduction, and not via induction of apoptosis.

Study Type : In Vitro Study

Print Options

Key Research Topics

Sayer Ji
Founder of GreenMedInfo.com

Subscribe to our informative Newsletter & get Nature's Evidence-Based Pharmacy

Our newsletter serves 500,000 with essential news, research & healthy tips, daily.

Download Now

500+ pages of Natural Medicine Alternatives and Information.

This website is for information purposes only. By providing the information contained herein we are not diagnosing, treating, curing, mitigating, or preventing any type of disease or medical condition. Before beginning any type of natural, integrative or conventional treatment regimen, it is advisable to seek the advice of a licensed healthcare professional.

© Copyright 2008-2022 GreenMedInfo.com, Journal Articles copyright of original owners, MeSH copyright NLM.