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Article Publish Status: FREE
Abstract Title:

Rosmarinic acid interferes with influenza virus A entry and replication by decreasing GSK3β and phosphorylated AKT expression levels.

Abstract Source:

J Microbiol Immunol Infect. 2022 May 18. Epub 2022 May 18. PMID: 35650006

Abstract Author(s):

Jia-Rong Jheng, Chung-Fan Hsieh, Yu-Hsiu Chang, Jin-Yuan Ho, Wen-Fang Tang, Zi-Yi Chen, Chien-Jou Liu, Ta-Jen Lin, Li-Yu Huang, Jyh-Haur Chern, Jim-Tong Horng

Article Affiliation:

Jia-Rong Jheng

Abstract:

BACKGROUND: The purpose of this study was to examine the in vivo activity of rosmarinic acid (RA) - a phytochemical with antioxidant, anti-inflammatory, and antiviral properties - against influenza virus (IAV). An antibody-based kinase array and different in vitro functional assays were also applied to identify the mechanistic underpinnings by which RA may exert its anti-IAV activity.

METHODS: We initially examined the potential efficacy of RA using an in vivo mouse model. A time-of-addition assay and an antibody-based kinase array were subsequently applied to investigate mechanism-of-action targets for RA. The hemagglutination inhibition assay, neuraminidase inhibition assay, and cellular entry assay were also performed.

RESULTS: RA increased survival and prevented body weight loss in IAV-infected mice. In vitro experiments revealed that RA inhibited different IAV viruses - including oseltamivir-resistant strains. From a mechanistic point of view, RA downregulated the GSK3β and Akt signaling pathways - which are known to facilitate IAV entry and replication into host cells.

CONCLUSIONS: RA has promising preclinical efficacy against IAV, primarily by interfering with the GSK3β and Akt signaling pathways.

Study Type : Animal Study, In Vitro Study

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