Article Publish Status: FREE
Abstract Title:

Effects of Royal Jelly Administration on Endurance Training-Induced Mitochondrial Adaptations in Skeletal Muscle.

Abstract Source:

Nutrients. 2018 Nov 12 ;10(11). Epub 2018 Nov 12. PMID: 30424505

Abstract Author(s):

Yumiko Takahashi, Kamiyu Hijikata, Kohei Seike, Suguru Nakano, Mai Banjo, Yosuke Sato, Kenya Takahashi, Hideo Hatta

Article Affiliation:

Yumiko Takahashi


We investigated the effect of royal jelly (RJ), a natural secretion from worker bees, on the endurance training-induced mitochondrial adaptations in skeletal muscles of ICR mice. Mice received either RJ (1.0 mg/g body weight) or distilled water for three weeks. The mice in the training group were subjected to endurance training (20 m/min; 60 min; 5 times/week). There was a main effect of endurance training on the maximal activities of the mitochondrial enzymes, citrate synthase (CS), andβ-hydroxyacyl coenzyme Adehydrogenase (β-HAD), in theand() muscles, while no effect of RJ treatment was observed. In themuscle, CS andβ-HAD maximal activities were significantly increased by endurance training in the RJ-treated group, while there was no effect of training in the control group. Furthermore, we investigated the effects of acute RJ treatment on the signaling cascade involved in mitochondrial biogenesis. In the, phosphorylation of 5'-AMP-activated protein kinase (AMPK) and acetyl-CoA carboxylase (ACC) were additively increased by a single RJ treatment and endurance exercise, while only an exercise effect was found in theandmuscles. These results indicate that the RJ treatment induced mitochondrial adaptation with endurance training by AMPK activation in the soleus muscles of ICR mice.

Study Type : Animal Study
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