Abstract Title:

Rutin as a Natural Therapy for Alzheimer's Disease: Insights into its Mechanisms of Action.

Abstract Source:

Curr Med Chem. 2016 Feb 17. Epub 2016 Feb 17. PMID: 26898570

Abstract Author(s):

Solomon Habtemariam

Article Affiliation:

Solomon Habtemariam


Rutin (quercetin-3-O-rutinoside) is a multifunctional natural flavonoid glycoside with profound effects on the various cellular functions under pathological conditions. Due to the ability of rutin and/or its metabolites to cross the blood brain barrier, it has also been shown to modify the cognitive and various behavioral symptoms of neurodegenerative diseases. In this review, its therapeutic potential for Alzheimer's disease (AD) is evaluated through appraisal of current literatures relevant to the various cellular and molecular targets of the disease. Among the most relevant mechanisms involved are effect on amyloid beta (Aβ) processing, aggregation and action; alteration of the oxidant-antioxidant balance associated with neuronal cell loss; removing the inflammatory component of neurodegeneration, etc. The effect of rutin resulting from its physicochemical features related to effects like metal chelation and bioavailability are also discussed.

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