Article Publish Status: FREE
Abstract Title:

Sasa borealis extract exerts an antidiabetic effect via activation of the AMP-activated protein kinase.

Abstract Source:

Nutr Res Pract. 2013 Feb ;7(1):15-21. Epub 2013 Feb 4. PMID: 23423690

Abstract Author(s):

Jung Soo Nam, Hee Jin Chung, Min Kyung Jang, In Ah Jung, Seong Ha Park, Su In Cho, Myeong Ho Jung

Article Affiliation:

Jung Soo Nam


Leaf of Sasa borealis, a species of bamboo, has been reported to exhibit anti-hyperglycemic effect. However, its antidiabetic mechanism is not fully understood. In this study, we examined whether an extract of S. borealis activates AMP-activated protein kinase (AMPK) and exerts anti-hyperglycemic effects. Treatment with the S. borealis extract increased insulin signaling and phosphorylation of AMPK and stimulated the expression of its downstream targets, including PPARα, ACO, and CPT-1 in C2C12 cells and PPARα in HepG2 cells. However, inhibition of AMPK activation attenuated insulin signaling and prevented the stimulation of AMPK target genes. The S. borealis extract increased glucose uptake in C2C12 cells and suppressed expression of the gluconeogenic gene, PEPCK in HepG2 cells. The extract significantly reduced blood glucose and triglyceride levels in STZ-induced diabetic mice. The extract enhanced AMPK phosphorylation and increased Glut-4 expression in the skeletal muscle of the mice. These findings demonstrated that the S. borealis extract exerts itsanti-hyperglycemic effect through activation of AMPK and enhancement of insulin signaling.

Study Type : Animal Study

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