Abstract Title:

Sabadinine: a potential non-peptide anti-severe acute-respiratory-syndrome agent identified using structure-aided design.

Abstract Source:

J Med Chem. 2004 Feb 26 ;47(5):1079-80. PMID: 14971887

Abstract Author(s):

Jeffrey H Toney, Sonia Navas-Martín, Susan R Weiss, Andreas Koeller

Article Affiliation:

Jeffrey H Toney


A novel human coronavirus has been reported to be the causative agent of severe acute respiratory syndrome (SARS). Since replication of HcoVs depends on extensive proteolytic processing, the main proteinase, 3CLpro, is an attractive drug target for anti-SARS agents. We have employed molecular docking of a chemical database into the active site of 3CLpro to search for non-peptidyl inhibitors. One compound was identified to be the natural product sabadinine, isolated from a historical herbal remedy.

Study Type : In Vitro Study

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