Abstract Title:

[A prospective control study ofin prevention of antibiotic-associated diarrhea in the older inpatients].

Abstract Source:

Zhonghua Nei Ke Za Zhi. 2017 Jun 1 ;56(6):398-401. PMID: 28592037

Abstract Author(s):

D M Zhang, B B Xu, L Yu, L F Zheng, L P Chen, W Wang

Article Affiliation:

D M Zhang


To study the value offor the prevention of antibiotic-associated diarrhea in older inpatients.A total of 163 older patients who were treated with wide-spectrum antibiotics at least three days during January 2014 to December 2015 were randomly divided into control and study group. In study group, 81 patients were administrated with oral500 mg twice a day for 21 days. The control group was of no intervention. Morbidity rate of antibiotic-associated diarrhea and-associated diarrhea, frequency and duration of diarrhea were recorded.The incidence of antibiotic-associated diarrhea in study group was significantly lower than that in control group [14.8%(12/81) vs 28.0%(23/82),<0.05], whereas no difference was seen in the incidence of-associated diarrhea [3.7%(3/81) vs 4.9%(4/82),>0.05] in two groups. The frequency and duration of diarrhea in the study group were significantly lower and shorter than those in control group[(4.3±1.7) times/day vs (6.9±2.0) times/day; (3.0±1.1) days vs (5.7±1.8) days, both<0.01].may reduce the incidence of antibiotic-associated diarrhea therefore improving the symptom of diarrhea in older inpatients.

Study Type : Human Study

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