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Abstract Title:

Saffron against Neuro-Cognitive Disorders: An Overview of Its Main Bioactive Compounds, Their Metabolic Fate and Potential Mechanisms of Neurological Protection.

Abstract Source:

Nutrients. 2022 Dec 17 ;14(24). Epub 2022 Dec 17. PMID: 36558528

Abstract Author(s):

Débora Cerdá-Bernad, Leonor Costa, Ana Teresa Serra, Maria Rosário Bronze, Estefanía Valero-Cases, Francisca Pérez-Llamas, María Emilia Candela, Marino B Arnao, Francisco Tomás Barberán, Rocío García Villalba, María-Teresa García-Conesa, María-José Frutos

Article Affiliation:

Débora Cerdá-Bernad

Abstract:

Saffron (L.) is a spice used worldwide as a colouring and flavouring agent. Saffron is also a source of multiple bioactive constituents with potential health benefits. Notably, saffron displays consistent beneficial effects against a range of human neurological disorders (depression, anxiety, sleeping alterations). However, the specific compounds and biological mechanisms by which this protection may be achieved have not yet been elucidated. In this review, we have gathered the most updated evidence of the neurological benefits of saffron, as well as the current knowledge on the main saffron constituents, their bioavailability and the potential biological routes and postulated mechanisms by which the beneficial protective effect may occur. Our aim was to provide an overview of the neuroprotective effects attributed to this product and its main bioactive compounds and to highlight the main research gaps that need to be further pursued to achieve full evidence and understanding of the benefits of saffron. Overall, improved clinical trials and adequately designed pre-clinical studies are needed to support the evidence of saffron and of its main bioactive components (e.g., crocin, crocetin) as a therapeutic product to combat neurological disorders.

Study Type : Review

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