Article Publish Status: FREE
Abstract Title:

Effect of saffron supplementation on symptoms of depression and anxiety: a systematic review and meta-analysis.

Abstract Source:

Nutr Rev. 2019 May 28. Epub 2019 May 28. PMID: 31135916

Abstract Author(s):

Wolfgang Marx, Melissa Lane, Tetyana Rocks, Anu Ruusunen, Amy Loughman, Adrian Lopresti, Skye Marshall, Michael Berk, Felice Jacka, Olivia M Dean

Article Affiliation:

Wolfgang Marx


CONTEXT: Saffron (Crocus sativus L.) has gained interest as a potential treatment in psychiatry.

OBJECTIVE: This systematic review and meta-analysis sought to investigate the effect of saffron supplementation, as both an adjunctive therapy and monotherapy, on symptoms of depression and anxiety in clinical and general populations compared with pharmacotherapy or placebo.

DATA SOURCES: Using the PRISMA guidelines, a systematic literature review of randomized controlled trials was conducted.

DATA EXTRACTION: A meta-analysis was conducted to determine treatment effect. Risk of bias was assessed using the Jadad scale.

RESULTS: Twenty-three studies were included. Saffron had a large positive effect size when compared with placebo for depressive symptoms (g = 0.99, P<0.001) and anxiety symptoms (g = 0.95, P<0.006). Saffron also had a large positive effect size when used as an adjunct to antidepressants for depressive symptoms (g = 1.23, P = 0.028). Egger's regression test found evidence of publication bias.

CONCLUSIONS: Saffron could be an effective intervention for symptoms of depression and anxiety; however, due to evidence of publication bias and lack of regional diversity, further trials are required. PROSPERO registration CRD42017070060.

Study Type : Meta Analysis, Review

Print Options

Key Research Topics

Sayer Ji
Founder of GreenMedInfo.com

Subscribe to our informative Newsletter & get Nature's Evidence-Based Pharmacy

Our newsletter serves 500,000 with essential news, research & healthy tips, daily.

Download Now

500+ pages of Natural Medicine Alternatives and Information.

This website is for information purposes only. By providing the information contained herein we are not diagnosing, treating, curing, mitigating, or preventing any type of disease or medical condition. Before beginning any type of natural, integrative or conventional treatment regimen, it is advisable to seek the advice of a licensed healthcare professional.

© Copyright 2008-2022 GreenMedInfo.com, Journal Articles copyright of original owners, MeSH copyright NLM.