Saffron hydroalcoholic extract may improve blood glucose control by reducing fasting blood sugar in T2D patients. - GreenMedInfo Summary

Background: Metabolic control is a major concern in preventing diabetic complications. Saffron as a natural source of antioxidants could play a role in alleviating diabetes insults. The aim of this study was to investigate effect of saffron hydroalcoholic extract on metabolic control in type 2 diabetes (T2D) mellitus.

Materials and Methods: This randomized triple blind study was included 54 T2D patients which randomly received either saffron (Group 1) or placebo (Group 2) twice daily other than routine antidiabetic treatments for 8 weeks. Serum concentration of fasting blood sugar (FBS), 2-h plasma glucose, hemoglobin A1c (HbA1c), total cholesterol, triglyceride (TG), low-density lipoprotein, and high-density lipoprotein were measured as the markers of metabolic control. Anthropometric measures and blood pressure were also measured at the baseline, every 2 weeks during the intervention and the end of the study. Data analyzed using repeated measure analysis of variance test.

Results: The baseline metabolic parameters were the same in two group (>0.01). FBS serum level significantly decreased within 8 weeks in the saffron group (128.84± 31.86) as compared to the placebo (153.76 ± 41.23), (<0.001). There was no statistical difference in other metabolic parameters such as serum lipids, blood pressure, and HbA1c (>0.01).

Conclusion: Saffron hydroalcoholic extract may improve blood glucose control by reducing FBS in T2D patients. However, saffron extract has no significant effect on other aspects of diabetic control in diabetic patients.