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Abstract Title:

Safranal, an active constituent of saffron, ameliorates myocardial ischemia via reduction of oxidative stress and regulation of Cahomeostasis.

Abstract Source:

J Pharmacol Sci. 2020 Jul ;143(3):156-164. Epub 2020 Mar 23. PMID: 32278466

Abstract Author(s):

Yurun Xue, Weiyue Jin, Yucong Xue, Yuanyuan Zhang, Hongfang Wang, Yixin Zhang, Shengjiang Guan, Xi Chu, Jianping Zhang

Article Affiliation:

Yurun Xue

Abstract:

Safranal (SFR) is the major constituent of saffron. The purpose of this study was to observe the effect of SFR on myocardial ischemia induced by isoprenaline (ISO) and to explore its possible mechanism. The myocardial ischemia rat model was established by subcutaneous injection of ISO (85 mg/kg/d) on the 8th and 9th day of the experiment. Serum creatine kinase (CK), lactate dehydrogenase (LDH), malondialdehyde (MDA) and superoxide dismutase (SOD) were measured, as were changes in calcium concentration, reactive oxygen species (ROS) and cardiac morphology of the myocardial tissue. The effects of SFR on cell contraction, Catransient and L-type Cacurrent (I) in isolated rat myocardial cells were measured using the Ion Optix detection system and the whole-cell patch-clamp technique. SFR can decrease the activity of serum CK, LDH and MDA, and increase the activity of serum SOD, reduce intracellular calcium concentration and the manufacture of ROS. In addition, SFR can improve changes in heart morphology. SFR can significantly inhibit contraction, Catransients and Iin isolated ventricular myocytes. SFR has a cardioprotective role in ISO-induced MI rats, and the underling mechanism is related to the inhibition of oxidative stress, myocardial contractility, Iand the regulation of Cahomeostasis.

Study Type : Animal Study

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