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Article Publish Status: FREE
Abstract Title:

Safranal Prevents Liver Cancer Through Inhibiting Oxidative Stress and Alleviating Inflammation.

Abstract Source:

Front Pharmacol. 2021 ;12:777500. Epub 2022 Feb 1. PMID: 35177980

Abstract Author(s):

Youssef Abdalla, Ali Abdalla, Alaaeldin Ahmed Hamza, Amr Amin

Article Affiliation:

Youssef Abdalla

Abstract:

Despite all efforts, an effective and safe treatment for liver cancer remains elusive. Natural products and their derived biomolecules are potential resources to mine for novel anti-cancer drugs. Chemopreventive effects of safranal, a major bioactive ingredient of the golden spice "saffron", were evaluated in this study against diethylnitrosamine (DEN)-induced liver cancer in rats. Safranal's mechanisms of action were also investigated in the human liver cancer line "HepG2". When administered to DEN-treated rats, safranal significantly inhibited proliferation (Ki-67) and also induced apoptosis (TUNEL and M30 CytoDeath). It also exhibited anti-inflammatory properties where inflammatory markers such as NF-kB, COX2, iNOS, TNF-alpha, and its receptor were significantly inhibited. Safranal'seffects were further supported in HepG2 cells where apoptosis was induced and inflammation was downregulated. In summary, safranal is reported here as a potent chemopreventive agent against hepatocellular carcinoma that may soon be an important ingredient of a broad-spectrum cancer therapy.

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