Abstract Title:

Gastroprotective constituents of Salvia officinalis L.

Abstract Source:

Fitoterapia. 2009 Oct;80(7):421-6. Epub 2009 May 28. PMID: 19481590

Abstract Author(s):

Bárbara Mayer, Cristiane Hatsuko Baggio, Cristina Setim Freitas, Ana Cristina dos Santos, André Twardowschy, Heros Horst, Moacir Geraldo Pizzolatti, Gustavo Amadeu Micke, Melina Heller, Elide Pereira dos Santos, Michel Fleith Otuki, Maria Consuelo Andrade Marques

Article Affiliation:

Departamento de Farmacologia, Setor de Ciências Biológicas, Universidade Federal do Paraná, Curitiba, PR, Brazil.


The gastrointestinal activity of hydroalcoholic extract (HE) of Salvia officinalis was evaluated in a model of ethanol-induced gastric lesion. HE showed excellent activity, with ID(50) 84.0 (54.8-128.9) mg/kg. The acetic acid-induced ulcer and the total acidity of the gastric secretion were also reduced by HE, and, in vitro experiments, the H(+),K(+)-ATPase activity was inhibited. Carnosol was identified as a possible active constituent for the gastroprotective effect of HE.

Study Type : In Vitro Study

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