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Article Publish Status: FREE
Abstract Title:

Bunge (Danshen) and Bioactive Compound Tanshinone IIA Alleviates Cisplatin-Induced Acute Kidney Injury Through Regulating PXR/NF-κB Signaling.

Abstract Source:

Front Pharmacol. 2022 ;13:860383. Epub 2022 Mar 24. PMID: 35401224

Abstract Author(s):

Jing-Yun Dou, Min Zhang, Huan Cen, Yi-Qin Chen, Yi-Fan Wu, Fuhua Lu, Jiuyao Zhou, Xu-Sheng Liu, Yue-Yu Gu

Article Affiliation:

Jing-Yun Dou

Abstract:

The present study aims to provide evidence on the potential protective role ofBunge (Danshen) and its bioactive compound Tanshinone IIA (TanIIA) in AKI and to reveal the specific regulatory function of PXR/NF-κB signaling in AKI-induced renal inflammation.A network pharmacological analysis was used to study target genes and regulatory networks in the treatment ofon AKI. Further experiments withAKI mouse model andstudies were applied to investigate the renal protective effect of TanIIA in AKI. The mechanisms of TanIIA regulating PXR/NF-κB signaling in renal inflammation were also studied.Network pharmacology had suggested the nuclear receptor family as new therapeutic targets ofin AKI treatment. Thestudies had demonstrated that TanIIA improved renal function and inflammation by reducing necrosis and promoting the proliferation of tubular epithelial cells. Improved renal arterial perfusion in AKI mice with TanIIA treatment was also recorded by ultrasonography.studies had shown that TanIIA ameliorated renal inflammation by activating the PXR while inhibiting PXR-mediated NF-κB signaling. The results had suggested a role of PXR activation against AKI-induced renal inflammation.Bunge (Danshen) may protect the kidneys against AKI by regulating nuclear receptors. TanIIA improved cell necrosis proliferation and reduced renal inflammation by upregulating the expression of the PXR and inhibiting NF-κB signaling in a PXR-dependent manner. The PXR may be a potential therapeutic target for AKI treatment.

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