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Abstract Title:

SARS-CoV-2 spike protein causes blood coagulation and thrombosis by competitive binding to heparan sulfate

Abstract Source:

. PMID: 34743814

Abstract Author(s):

Yi Zheng, Jinxiang Zhao, Jiaqi Li, Zhimou Guo, Jiajing Sheng, Xianlong Ye, Gaowa Jin, Chaoran Wang, Wengang Chai, Jingyu Yan, Dong Liu, Xinmiao Liang

Article Affiliation:

Yi Zheng

Abstract:

Thrombotic complication has been an important symptom in critically ill patients with COVID-19. It has not been clear whether the virus spike (S) protein can directly induce blood coagulation in addition to inflammation. Heparan sulfate (HS)/heparin, a key factor in coagulation process, was found to bind SARS-CoV-2 S protein with high affinity. Herein, we found that the S protein can competitively inhibit the bindings of antithrombin and heparin cofactor II to heparin/HS, causing abnormal increase in thrombin activity. SARS-CoV-2 S protein at a similar concentration (~10 μg/mL) as the viral load in critically ill patients can cause directly blood coagulation and thrombosis in zebrafish model. Furthermore, exogenous heparin/HS can significantly reduce coagulation caused by S protein, pointing to a potential new direction to elucidate the etiology of the virus and provide fundamental support for anticoagulant therapy especially for the COVID-19 critically ill patients.

Study Type : Animal Study
Additional Links
Additional Keywords : SARS-CoV-2 Spike Protein

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Sayer Ji
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