Abstract Title:

Triterpenoids from Schisandra lancifolia with anti-HIV-1 activity.

Abstract Source:

J Nat Prod. 2006 Feb;69(2):277-9. PMID: 16499331

Abstract Author(s):

Wei-Lie Xiao, Ren-Rong Tian, Jian-Xin Pu, Xian Li, Li Wu, Yang Lu, Sheng-Hong Li, Rong-Tao Li, Yong-Tang Zheng, Qi-Tai Zheng, Han-Dong Sun

Article Affiliation:

State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650204, Yunnan, People's Republic of China.


A new trinorcycloartane triterpenoid, lancifodilactone H (1), and a new A ring-secocycloartane triterpenoid, lancifoic acid A (2), together with a known compound, nigranoic acid (3), were isolated from the leaves and stems of Schisandra lancifolia. Their structures were elucidated by spectroscopic data analysis. Compound 1 features a biosynthetically modified seven-membered lactone ring, which was confirmed by single-crystal X-ray diffraction. Compounds 1-3 exhibited weak anti-HIV-1 activity in vitro.

Study Type : In Vitro Study
Additional Links
Pharmacological Actions : Anti-HIV Agents : CK(133) : AC(84)

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