Abstract Title:

Chemical constituents from the leaves and stems of Schisandra rubriflora.

Abstract Source:

J Nat Prod. 2010 Feb 10. Epub 2010 Feb 10. PMID: 20146529

Abstract Author(s):

Wei-Lie Xiao, Shi-Ying Yang, Liu-Meng Yang, Guang-Yu Yang, Rui-Rui Wang, Hai-Bo Zhang, Wei Zhao, Jian-Xin Pu, Yang Lu, Yong-Tang Zheng, Han-Dong Sun


Six new nortriterpenoids, schirubridilactones A-F (1-6), as well as 14 known compounds, were isolated from the leaves and stems of Schisandra rubriflora. The structures of 1-6 were elucidated on the basis of spectroscopic methods including HSQC, HMBC, (1)H-(1)H COSY, and ROESY NMR experiments. The relative stereochemistry of 1 was confirmed through single-crystal X-ray analysis. In addition, compounds 1-6 showed anti-HIV-1 activity with EC(50) values in the range 14.3-80.8 mug/mL and selectivity indices in the range 2.2-9.0.

Study Type : In Vitro Study

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