Abstract Title:

Antifungal triterpene glycosides from the sea cucumber Bohadschia marmorata.

Abstract Source:

Planta Med. 2008 Dec 18. PMID: 19096993

Abstract Author(s):

Wei-Hua Yuan, Yang-Hua Yi, Hai-Feng Tang, Bao-Shu Liu, Zeng-Lei Wang, Guo-Quan Sun, Wen Zhang, Ling Li, Peng Sun


Four new holostan-type triterpene glycosides, marmoratoside A ( 1), 17 alpha-hydroxy impatienside A ( 2), marmoratoside B ( 3), 25-acetoxy bivittoside D ( 4), together with two known triterpene glycosides, impatienside A ( 5) and bivittoside D ( 6), were isolated from the sea cucumber BOHADSCHIA MARMORATA Jaeger. On the basis of spectroscopic analyses, including two-dimensional NMR techniques, and chemical reactions, the structures of the new triterpene glycosides were elucidated. Compounds 1, 2, 5, and 6 exhibited significant antifungal activity against six strains (0.70 </= MIC (80) </= 2.81 muM).

Study Type : In Vitro Study

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