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Abstract Title:

Seabuckthorn polysaccharide combined withpolysaccharide ameliorate alcoholic fatty liver by regulating intestinal flora.

Abstract Source:

Front Endocrinol (Lausanne). 2022 ;13:1018557. Epub 2022 Sep 29. PMID: 36246879

Abstract Author(s):

Jiayue Liu, Lingzhou Kong, Mengting Shao, Changhai Sun, Changxu Li, Yanyan Wang, Xue Chai, Yuliang Wang, Yu Zhang, Xiaoliang Li, Hong Zhao

Article Affiliation:

Jiayue Liu

Abstract:

BACKGROUND: At present, the incidence of alcoholic fatty liver disease (AFLD) is increasing year by year, and numerous studies have confirmed that liver diseases are closely related to intestinal flora. Seabuckthorn and, as traditional Chinese medicine (TCM) with the homology of medicine and food, have good liver protection, and their polysaccharides can regulate the intestinal flora. Here, we studied the effects of HRP, APS and the combination of the two polysaccharides on the intestinal flora of AFLD mice, which provided scientific basis for the treatment of AFLD with the two polysaccharides.

MATERIALS AND METHODS: Thirty Kunming (KM) mice were randomly divided into the control group (Con), the model group (Mod), the HRP treatment group (HRP), the APS treatment group (APS), and HRP+APS treatment group (HRP+APS), with six mice in each group. The AFLD model was constructed by continuous intragastric administration of 42% vol Niulanshan ethanol solution for 28 days, and the mice in each polysaccharide group were given corresponding drugs. The levels of AST, ALT, TC and TG in serum of mice were measured. 16S rRNA amplicon sequencing technique was used to determine the diversity and richness of intestinal flora, and the relative abundance of intestinal flora at phylum level and genus level of the mice in each group.

RESULTS: HRP, APS and HRP+APS could reduce the serum levels of AST, ALT, TC and TG in mice. In addition, HRP, APS and HRP + APS restored the diversity, relative abundance and community structure of intestinal mucosa bacteria in AFLD mice to a certain extent. Specifically, HRP, APS and HRP+APS remarkably decreased the ratio ofto, and ultimately increased the abundance of beneficial bacteria and reduced the abundance of pathogenic bacteria.

CONCLUSION: HRP, APS, and HRP+APS can improve the intestinal microecology of AFLD model mice, alleviate liver injury, and maintain normal intestinal function in different degrees.

Study Type : Animal Study

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