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Abstract Title:

Secoiridoid dimers and their biogenetic precursors from the fruits of Cornus officinalis with potential therapeutic effects on type 2 diabetes.

Abstract Source:

Bioorg Chem. 2021 Dec ;117:105399. Epub 2021 Oct 4. PMID: 34688131

Abstract Author(s):

Zhong-Can Peng, Jun He, Xue-Ge Pan, Jia Zhang, Yu-Ming Wang, Xian-Sheng Ye, Cong-Yuan Xia, Wen-Wen Lian, Yu Yan, Xiao-Li He, Wei-Ku Zhang, Jie-Kun Xu

Article Affiliation:

Zhong-Can Peng

Abstract:

Cornusdiridoid A-F (1-6), six unusual cornuside-morroniside secoiridoid dimers, and their possible new biogenetic precursor, 3″,5″-dehydroxycornuside (7), together with four known secoiridoids (8-11), were obtained from the fruits of Cornus officinalis. Their structures were elucidated on the basis of various spectroscopic and chemical methods. A plausible biosynthetic pathway of compounds 1-11 was proposed. The α-glucosidase inhibitory, antioxidant and anti-inflammatory activities of these isolates were evaluated. Some of them emerged out as potent antidiabetic, anti-inflammatory and free radical scavenging agents. Molecular docking was also carried out for antidiabetic target α-glucosidase to investigate thepossible binding modes of the most potent α-glucosidase inhibitor, vincosamide (9). These results revealed that the secoiridoids from C. officinalis fruits may be served as new potential antidiabetic agents to prevent and treat type 2 diabetes.

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