Abstract Title:

Anti-tumor and immunomodulatory activity of selenium (Se)-polysaccharide from Se-enriched Grifola frondosa.

Abstract Source:

Int J Biol Macromol. 2016 Jan ;82:607-13. Epub 2015 Oct 30. PMID: 26522247

Abstract Author(s):

Guang-Hua Mao, Yi Ren, Qian Li, Hui-Yu Wu, Dun Jin, Ting Zhao, Cai-Quan Xu, Deng-Hong Zhang, Qing-Dong Jia, Yan-Peng Bai, Liu-Qing Yang, Xiang-Yang Wu

Article Affiliation:

Guang-Hua Mao


A polysaccharide termed Se-GP11 was extracted and purified from Se-enriched Grifola frondosa in our previous study. This study investigated the characterization, anti-tumor and immunomodulatory activity of Se-GP11. The results showed that Se-GP11 was composed of mannose, glucose and galactose with a molar ratio of 1:4.91:2.41. The weight-average molecular weight (Mw) and weight-average mean square radius (Rw) of Se-GP11 in 0.1M sodium chloride solution were 3.3×10(4)Da and 32.8nm. Se-GP11 existed as a globular conformation with random coil structure. Se-GP11 had no anti-tumor activity against HepG-2 cells in vitro, and it significantly inhibited the growth of Heps tumor in vivo. Se-GP11 increased the relatively thymus and spleen weights as well as serumnecrosis factor-alpha (TNF-α) and interleukin-2 (IL-2) levels. In addition, Se-GP11 promoted the phagocytosis and NO production of RAW264.7 as compared with that of the normal control group. The results revealed that the Se-GP11 may exhibit the anti-tumor through improving immunologic function of the tumor bearing mice.

Study Type : Animal Study

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