Article Publish Status: FREE
Abstract Title:

Associations between Obesity, Body Fat Distribution, Weight Loss and Weight Cycling on Serum Pesticide Concentrations.

Abstract Source:

J Food Nutr Disord. 2016;5(3). Epub 2016 Jun 25. PMID: 27478857

Abstract Author(s):

Andrew Dandridge Frugé, Mallory Gamel Cases, Joellen Martha Schildkraut, Wendy Demark-Wahnefried

Article Affiliation:

Andrew Dandridge Frugé


OBJECTIVE: Preliminary studies suggest pesticides may be linked to increased cancer risk. Since most pesticides are lipophilic and stored within adipose tissue, serum levels of organochlorines are affected not only by environmental exposures, but also by factors related to lipid turnover and storage. Our objective was to investigate whether serum organochlorines are influenced by weight loss, body fat distribution, and weight cycling.

METHODS: Ten overweight women were recruited upon entry into a weight loss program and surveyed regarding weight history, childbearing/lactation, and exposure to environmental contaminants. Anthropometric measures and phlebotomy were conducted at baseline and at four weeks (mean weight loss=5.1 kg). Serum was analyzed for 19 common polychlorinated pesticides and metabolites and 10 PCB congeners.

RESULTS: Organochlorine levels were not significantly affected by weight loss nor associated with body mass index (BMI). Strong positive correlations were noted between levels of DDE/DDT and age (DDEβ=0.6986/p=0.0246/DDT β=0.6536/p=0.0404) and between DDE/DDT and waist-to-hip ratio (WHR) (DDE β=0.4356/p=0.0447/DDT β=0.8108/p=0.0044). Trends were noted for decreased levels of DDT in women who reported more episodes of weight cycling.

CONCLUSION: Serum organochlorine levels may be affected not only by age, but also factors related to lipid turnover (i.e., episodes of weight cycling and WHR), and warrants further study.

Study Type : Human Study

Print Options

Key Research Topics

Sayer Ji
Founder of GreenMedInfo.com

Subscribe to our informative Newsletter & get Nature's Evidence-Based Pharmacy

Our newsletter serves 500,000 with essential news, research & healthy tips, daily.

Download Now

500+ pages of Natural Medicine Alternatives and Information.

This website is for information purposes only. By providing the information contained herein we are not diagnosing, treating, curing, mitigating, or preventing any type of disease or medical condition. Before beginning any type of natural, integrative or conventional treatment regimen, it is advisable to seek the advice of a licensed healthcare professional.

© Copyright 2008-2022 GreenMedInfo.com, Journal Articles copyright of original owners, MeSH copyright NLM.