Abstract Title:

Protective effect of daily sesame oil supplement on gentamicin-induced renal injury in rats.

Abstract Source:

Biol Pharm Bull. 2001 Feb;24(2):181-7. PMID: 19487986

Abstract Author(s):

Dur-Zong Hsu, Chuan-Teng Liu, Ya-Hui Li, Pei-Yi Chu, Ming-Yie Liu


Gentamicin, an aminoglycoside antibiotic, is widely used in the treatment of Gramnegative infections; however, dose-limiting nephrotoxicity restricts its optimal use. We investigated the effect of a daily sesame oil supplement on oxidative-stress-associated renal injury induced by a single daily dose of gentamicin in rats. Renal injury was induced by a single subcutaneous daily dose of gentamicin (100 mg/kg/day for 7 days), and then the effects of oral sesame oil (0.25, 0.5, and 1 mL/kg/day for 7 days) on renal injury, oxidative stress, hydroxyl radical, superoxide anion, and nitric oxide were assessed after treatment. Sesame oil inhibited gentamicin-induced renal injury, lipid peroxidation, hydroxyl radical, and superoxide anion, as well as nitric oxide production. In addition, sesame oil inhibited xanthine oxidase activity and inducible nitric oxide synthase expression in gentamicin-challenged rats. We hypothesize that a daily sesame oil supplement attenuates oxidativestress-associated renal injury by reducing oxygen free radicals and lipid peroxidation in gentamicin-treated rats.

Study Type : Animal Study

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