Abstract Title:

Acute and long-term hemodynamic effects of sesame oil consumption in hypertensive men.

Abstract Source:

J Clin Hypertens (Greenwich). 2012 Sep ;14(9):630-6. Epub 2012 May 24. PMID: 22947362

Abstract Author(s):

Kalliopi Karatzi, Kimon Stamatelopoulos, Marita Lykka, Pigi Mantzouratou, Sofia Skalidi, Efstathios Manios, George Georgiopoulos, Nikolaos Zakopoulos, Christos Papamichael, Labros S Sidossis

Article Affiliation:

From the Department of Nutrition and Dietetics, Harokopio University, Athens, Greece;the Vascular Laboratory, Department of Clinical Therapeutics, Alexandra University Hospital, Athens, Greece;the Department of Internal Medicine-Geriatrics, Sealy Center on Aging, Institute for Translational Sciences and Shriners Hospital for Children, University of Texas Medical Branch at Galveston, Galveston, TX.


J Clin Hypertens (Greenwich). 2012; 14:630-636.© 2012 Wiley Periodicals, Inc. The possible effects of sesame oil on hemodynamics are unknown. The aim of the study was to investigate the acute and long-term effects of sesame oil on hemodynamic responses in hypertensive men. The authors enrolled 30 hypertensive men in a two-phase study. In the first phase, patients consumed 35 g of either sesame oil or control oil. Central and peripheral blood pressure, pulse wave velocity, augmentation index (AI), C-reactive protein, tumor necrosis factor α, malonydealdehyde, and total antioxidant capacity (TAC) were assessed at fast and 2 hours postprandially. In the second phase, patients consumed 35 g of either sesame oil or control oil daily for 2 months. The above-mentioned parameters were assessed before and following 15, 30, and 60 days of oil consumption. Sesame oil decreased central and peripheral diastolic pressures 1 hour postprandially (P=.006). Fifteen days of sesame oil intake decreased peripheral systolic blood pressure (P=.016) and heart rate-corrected AI75 (P=.017) and increased TAC (P=.007). This is the first study to demonstrate a favorable acute and long-term effect of sesame oil on hemodynamics in hypertensivemen. Further research is warranted to establish the potential protective role of sesame oil.

Study Type : Human Study
Additional Links
Pharmacological Actions : Hypotensive : CK(467) : AC(63)

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