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Abstract Title:

Sesamin attenuates carrageenan-induced lung inflammation through upregulation of A20 and TAX1BP1 in rats.

Abstract Source:

Int Immunopharmacol. 2020 Nov ;88:107009. Epub 2020 Sep 22. PMID: 33182047

Abstract Author(s):

He Ye, Liyan Sun, Jun Li, Yayun Wang, Junzhe Bai, Liang Wu, Qi Han, Zhiping Yang, Li Li

Article Affiliation:

He Ye

Abstract:

Sesamin is a major component in lignans of sesame seeds, has been described to possess a lot of biological activity. The main objective of our study was to investigate the inhibitory effect and novel molecular mechanisms of sesamin on carrageenan-induced lung inflammation in rats. Here we showed that sesamin can obviously reduce polymorphonuclear neutrophils infiltration and exudate volume. Further studies exhibited sesamin can inhibit cytokines release, polymorphonuclear neutrophils markers production and the degree of lung tissues injury. Western blot analysis revealed that sesamin can inhibit the TRAF6 expression and NF-κB pathway activation in lung tissue. We found that sesamin can increase the expression of A20 and TAX1BP1 in lung tissues, and the interaction between the two molecules. In conclusion, all these results demonstrated that sesamin can attenuate carrageenan-induced lung inflammation, the mechanisms that may be related to upregulation of the novel target A20 and TAX1BP1 which can negative regulation for NF-κB pathway. Importantly, this is the first evidence showing that TAX1BP1 can be as a novel regulatory target to attenuate the lung inflammation.

Study Type : Animal Study

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