Abstract Title:

Effects of (-)-Sesamin on Chronic Stress-Induced Anxiety Disorders in Mice.

Abstract Source:

Neurochem Res. 2016 Dec 19. Epub 2016 Dec 19. PMID: 27995494

Abstract Author(s):

Ting Ting Zhao, Keon Sung Shin, Hyun Jin Park, Bo Ram Yi, Kyung Eun Lee, Myung Koo Lee

Article Affiliation:

Ting Ting Zhao


This study investigated the effects of (-)-sesamin on chronic electric footshock (EF) stress-induced anxiety disorders in mice. Mice were treated with (-)-sesamin (25 and 50 mg/kg) orally once a day for 21 days prior to exposure to EF stress (0.6 mA, 1 s every 5 s, 3 min). Mice treated with (-)-sesamin (25 and 50 mg/kg) exhibited less severe decreases in the number of open arm entries and time spent on open arms in the elevated plus-maze test and the distance traveled in the open field test following exposure to chronic EF stress. Similarly, mice treated with (-)-sesamin exhibited significantly less severe decreases in brain levels of dopamine, norepinephrine, and serotonin following exposure to chronic EF stress. Increases in serum levels of corticosteroneand expression of c-Fos were also less pronounced in mice treated with (-)-sesamin (25 and 50 mg/kg). These results suggest that (-)-sesamin may protect against the effects of chronic EF stress-induced anxiety disorders by modulating dopamine, norepinephrine, and serotonin levels, c-Fos expression, and corticosterone levels.

Study Type : Animal Study
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Diseases : Anxiety

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