Sesamol has wound healing properties. - GreenMedInfo Summary

Abstract Title:

Normal and delayed wound healing is improved by sesamol, an active constituent of Sesamum indicum (L.) in albino rats.

Abstract Source:

J Ethnopharmacol. 2011 Jan 27 ;133(2):608-12. Epub 2010 Oct 28. PMID: 21035533

Abstract Author(s):

Rekha R Shenoy, Arun T Sudheendra, Pawan G Nayak, Piya Paul, N Gopalan Kutty, C Mallikarjuna Rao

Article Affiliation:

Department of Pharmacology, Manipal College of Pharmaceutical Sciences, Manipal University, Manipal 576104, Karnataka, India.


UNLABELLED: ETHNO-PHARMACOLOGICAL RELEVANCE: The seeds of Sesamum indicum Linn. (Pedaliaceae) has been used traditionally for the treatment of wounds in Buldhana district of Maharashtra state. Sesamol is the main anti-oxidative constituent contained mainly in the processed sesame seed oil which has not been explored scientifically for its wound healing activity.

AIM OF THE STUDY: To investigate the influence of sesamol (SM) on wound repair, both in normal and dexamethasone (DM) delayed healing processes in albino rats.

MATERIALS AND METHODS: Incision, excision and dead space wounds were inflicted on albino rats (180-220 g) of either sex, under ketamine anaesthesia. Group I served as control, group II received SM 50 mg/kg i.p., group III was treated with dexamethasone (DM) i.m. (0.17 mg/kg) and SM+DM was given to group IV. The tensile strength, wound contraction, hydroxyproline, lysyl oxidase and total RNA and DNA levels (in granulation tissue) were measured.

RESULTS: The tensile strength significantly (p<0.05) increased with SM at 471.40±14.66 g when compared to control at 300.60±9.16 g in normal and DM suppressed healing. No significant change was observed in duration of wound contraction and lysyl oxidase when compared to control at 2.98±0.10 mg. SM treated rats showed a significant (p<0.05) rise in hydroxyproline levels at 6.45±0.45 mg when compared to control at 1.75±0.20 mg.

CONCLUSION: These results indicate that sesamol could be a promising drug in normal as well as delayed wound healing processes.

Study Type : Animal Study

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