Abstract Title:

The prophylactic protective effect of sesamol against ferric-nitrilotriacetate-induced acute renal injury in mice.

Abstract Source:

Food Chem Toxicol. 2008 Aug ;46(8):2736-41. Epub 2008 Apr 29. PMID: 18539378

Abstract Author(s):

Dur-Zong Hsu, Chang-Hsin Wan, Hua-Fen Hsu, Yung-Ming Lin, Ming-Yie Liu

Article Affiliation:

Department of Environmental and Occupational Health, National Cheng Kung University Medical College, 138 Sheng-Li Road, Tainan, Taiwan.


The aim of this study was to examine the prophylactic protective effects of 3,4-methylenedioxyphenol (sesamol) on ferric-nitrilotriacetate (Fe-NTA)-induced acute renal damage in mice. We induced acute renal injury in mice by treating them with 4 mg/kg of Fe-NTA for 3h. We used blood biochemistry, creatinine clearance, and histological examinations to assess renal function. With a high-performance chemiluminescence analyzer, we also determined the hydroxyl radical and superoxide anion levels (free radicals) generated. Renal xanthine oxidase activities were also assessed. Sesamol inhibited Fe-NTA-induced acute renal injury, renal lipid peroxidation, the levels of renal hydroxyl radical and superoxide anion generated, and the activity of xanthine oxidase in mice. Therefore, we concluded that sesamol protected mice against Fe-NTA-induced oxidative-stress-associated acute renal injury by at least partially inhibiting the production of reactive oxygen species.

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