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Article Publish Status: FREE
Abstract Title:

Low vitamin D levels are associated with the presence of serum cryoglobulins in patients with chronic HCV infection.

Abstract Source:

In Vivo. 2015 May-Jun;29(3):399-404. PMID: 25977388

Abstract Author(s):

Ivan Gentile, Filomena Scarano, Anna Celotti, Enrica DE Iuliis, Rosanna Scarano, Vincenza Granata, Biagio Pinchera, Mariangela Meola, Antonietta D'Ambra, Mauro Piccirillo, Flaviano DI Paola, Ernesta Cavalcanti, Francesco Izzo, Nicola Scarpato, Guglielmo Borgia

Article Affiliation:

Ivan Gentile

Abstract:

BACKGROUND/AIM: Mixed Cryoglobulinemia (MC) represents the most frequent extrahepatic manifestation of chronic Hepatitis C Virus (HCV) infection. Its pathogenic mechanisms involve HCV-induced chronic stimulation of B-lymphocytes. We aimed to investigate the relationship between serum levels of vitamin D (a regulator of immune response) and the presence of serum cryoglobulins in the setting of HCV infection.

PATIENTS AND METHODS: We evaluated the serum concentration of 25(OH)vitamin D and cryoglobulins in 106 patients with chronic HCV infection.

RESULTS: Thirty patients (28.3%) showed the presence of serum cryoglobulins. For the cohort overall, the median serum 25(OH)vitamin D level was 10.95 ng/ml. Patients with serum cryoglobulins had significantly lower levels of 25(OH)vitamin D (5.61 ng/ml) than those without (13.65 ng/ml, p=0.029). At multivariate analysis, severe hypovitaminosis [i.e. 25(OH)vitamin D<13 ng/ml] was the only independent predictor of cryoglobulinemia (odds ratio=3.108).

CONCLUSION: Severe deficiency of vitamin D was independently associated with mixed cryoglobulinemia in patients with HCV infection.

Study Type : Human Study

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