Abstract Title:

Day and night aspirin-induced gastric mucosal damage and protection by ranitidine in man.

Abstract Source:

Chronobiol Int. 1987 ;4(1):111-6. PMID: 3677213

Abstract Author(s):

J G Moore, R H Goo

Article Affiliation:

J G Moore


The severity of gastric mucosal injury produced by aspirin (ASA) was endoscopically assessed during morning and evening studies in 10 healthy, male volunteers. In a randomized, double-blind design, subjects received either ASA (1300 mg) alone or ASA (1300 mg) plus Ranitidine (150 mg) or placebo tablets during morning and evening studies. Each subject had 3 morning and 3 evening studies. The severity of damage produced by ASA was assessed by counting the number of punctate mucosal hemorrhages observed in the gastric antrum and low-body. This study demonstrated (1) wide intersubject variability in the severity of damage produced by ASA (range of 47-1030 lesions/subject in morning studies), (2) significant protection against ASA-induced damage by Ranitidine and (3) significantly greater damage produced by ASA in the morning compared to the evening studies. Because evening acid secretory rates are higher and because ASA-induced damage is believed to be acid-dependent, this last observation was unexpected. It suggests mucosal resistance is higher in the evening and raises the possibility that there may be circadian variation in gastric mucosal resistance.

Study Type : Human Study
Additional Links
Additional Keywords : Circadian Rhythm : CK(23) : AC(4)
Problem Substances : Aspirin : CK(600) : AC(97)

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