Abstract Title:

Chronic Supplementation With Shark Liver Oil for Reducing Tumor Growth and Cachexia in Walker 256 Tumor-Bearing Rats.

Abstract Source:

Nutr Cancer. 2011 Oct 7. Epub 2011 Oct 7. PMID: 21981555

Abstract Author(s):

Fabíola Iagher, Sérgio Ricardo de Brito Belo, Katya Naliwaiko, Andressa Machado Franzói, Gleisson Alisson Pereira de Brito, Ricardo Key Yamazaki, Ana Lúcia Muritiba, Luis Alexandre Muehlmann, Jovani Antonio Steffani, Luiz Cláudio Fernandes

Article Affiliation:

a Area of Biological and Health Sciences , West University of Santa Catarina , Joaçaba , Brazil.


We investigated the effect of chronic supplementation with shark liver oil (SLO), an antitumor supplement source of n-3 fatty acids and 1-O-alkylglycerols, alone and combined with coconut fat (CF), a source of saturated fatty acids, on Walker 256 tumor growth and cachexia. Male rats were supplemented daily and orally with SLO and/or CF (1 g per kg body weight) for 7 wk. After 7 wk, 50% of animals were subcutaneously inoculated with 3 × 10(7) Walker 256 tumor cells. After 14 days, the rats were killed, the tumors were removed for lipid peroxidation measurement, and blood was collected for glycemia, triacylglycerolemia, and lacticidemia evaluation. Liver samples were obtained for glycogen measurement. Unlike CF, supplementation with SLO promoted gain in body weight, reduction of tumor weight, and maintained glycemia, triacylglycerolemia, lacticidemia, and liver glycogen content to values similar to non-tumor-bearing rats. Combined supplementation of SLO with CF also showed a reversion of cachexia with gain in body mass, reduction of lacticidemia, maintaining the liver glycogen store, and reduction in tumor weight. SLO, alone or combined with CF, promoted increase of tumor lipid peroxidation. In conclusion, SLO supplemented chronically, alone or associated with CF, was able to reduce tumor growth and cachexia.

Study Type : Animal Study

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