Shiitake contains compounds with hypoglycemic activity in a rat model of type 1 diabetes. - GreenMedInfo Summary

Abstract Title:

Hypoglycemic effect of a Lentinus edodes exo-polymer produced from a submerged mycelial culture.

Abstract Source:

Biosci Biotechnol Biochem. 2002 May;66(5):937-42. PMID: 12092843

Abstract Author(s):

Byung-Keun Yang, Dong-Hyun Kim, Sang-Chul Jeong, Surajit Das, Young-Sun Choi, Joon-Shik Shin, Sang-Chul Lee, Chi-Hyun Song

Abstract:

The hypoglycemic effect of an exo-polymer produced from a submerged mycelial culture of Lentinus edodes was investigated in streptozotocin-induced diabetic rats. The administration of the exo-polymer (200 mg/kg BW) reduced the plasma glucose level by as much as 21.5%, and increased plasma insulin by 22.1% as compared to the control group. It also lowered the plasma total cholesterol and triglyceride levels by 25.1 and 44.5%, respectively. Gel chromatography of the exo-polymer revealed a single peak which is likely to have been a glycoprotein with a molecular weight of 52 kDa and was found to contain 83.5% carbohydrate and 16.5% protein. The Sugar and amino acid compositions of the exo-polymer were analyzed in detail.

Article Published Date : May 01, 2002
Study Type : Animal Study
Additional Links
Substances : Shiitake Mushroom : CK(136) : AC(61)
Diseases : Diabetes Mellitus: Type 1 : CK(2032) : AC(611), Triglycerides: Elevated : CK(979) : AC(160)
Pharmacological Actions : Hypoglycemic Agents : CK(9221) : AC(2076)

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Key Research Topics

Substance

Shiitake Mushroom

Disease

Diabetes Mellitus: Type 1
Triglycerides: Elevated

Pharmacological Actions

Hypoglycemic Agents

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